Fusao Takusagawa
- Emeritus Professor
Contact Info
Personal Links
Biography —
- Director of X-ray Crystallography Laboratory, and Associate Scientist, University of Kansas, Lawrence, KS, 9/1984 - 7/1995.
- Director of X-ray Crystallography Laboratory, Senior Scientist, and Research Professor, University of Kansas, Lawrence, KS, 9/1995 - 7/1996.
- Associate Professor, Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 8/1996 - 8/2001
- Professor, Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 8/2001 - 2017
Fusao Takusagawa retired from KU in 2017.
Education —
B.S. in Chemical Engineering, Yamanashi University, Yamanashi, Japan
Ph.D. in Physical Chemistry, Osaka City University, Osaka, Japan
Ph.D. in Postdoctoral Research: E.R.D.A, Ames Laboratory, Iowa State University
Research —
- Structure and function of proteins and nucleic Acids.
- Design and synthesis of anti-viral and anti-cancer drugs.
- Development of computer software for crystallography.
Selected Publications —
- Takusagawa F & *Koetzle TF (1979). A Neutron Diffraction Study of the Crystal Structure of Ferrocence. Acta Cryst. B35, 1074
- Devore DD, Lichtenhan JD, *Maata EA & Takusagawa F (1987). Complexes of (Arylimido)vanadium(V): Synthetic,
Structural, Spectroscopic and Theoretical Studies of V(Ntol) Cl3 and Derivatives. J. Am. Chem. Soc. 109, 7408. - Kamitori S & *Takusagawa F (1992). Crystal Structure of 2:1 Complex Between d(GAAGCTTC) and Anticancer Drug Actinomycin. J. Mol. Biol. 225, 445.
- Takusagawa F, Kamitori S, Misaki S & Markham GD (1996). Crystal Structure of S-Adenosylmethionine Synthetase. J. Biol. Chem. 271, 136-147.
- Takusagawa F, Kamitori S & Markham GD (1996). Structure and Function of S- Adenosylmethionine Synthetase: Crystal Structure of S-Adenosylmethionine Synthetase with ADP, Br-ADP, PPi at 2.8Å Resolution. Biochemistry 35, 2586- 2596.
- Komoto J, Yamada T, Watanabe K, & *Takusagawa F (2004). Crystal structure of Human prostaglandin F synthase (AKR1C3). Biochemistry 43, 2188-2198.
Grants & Other Funded Activity —
- NIH: Study of interaction between DNA and antibiotics
- NIH: Structural studies of important enzymes
- Wesley Foundation: Study of DNA-drug interaction using X-ray crystallography
- NIH: Structural studies of important enzymes
- Kansas Health Foundation: Study of RNA-DNA hybrid binding agents
- J.R. & I. Jay Res. Fund: Roles of amino acids in actinomycin D
- NIH: Structural studies of important enzymes
- NIH: Structural studies of important enzymes
- NIH: Structural studies of important enzymes
- AmHeart: Studies of hyperhomocysteinemia
- Allegan Inc: Research of Endocrabinoids Synthase
- Arthritis Foundation: A study of prostaglandin E synthase induced by inflammatory responses
- KCALI: Control of Gap Junctions as a Neuro-protective Therapy
Training Grants
- NIH: Medicinal Chemistry & Pharmacology
- NIH: Training Grant in Dynamic Aspects of Chemical Biology
- NIH: Training Grant in Dynamic Aspects of Chemical Biology
- NIH: Training Grant in Dynamic Aspects of Chemical Biology
- NIH: Pharmaceutical Aspects of Biotechnology Training Grant