Felipe Teixeira

Felipe Teixeira
  • Postdoc, Lundquist Lab

Contact Info

5049 Haworth Hall

Biography —

Hometown: Rio de Janeiro, Brazil

Education —

Ph.D. in Microbiology, Federal University of Rio de Janeiro, 2016, Rio de Janeiro, RJ, Brazil
M.S. in Microbiology, Federal University of Rio de Janeiro, 2012, Rio de Janeiro, RJ, Brazil
B.S. in Biological Sciences: Microbiology and Immunology, Federal University of Rio de Janeiro, 2011, Rio de Janeiro, RJ, Brazil

Research —

During my PhD, I studied the transcriptomic response of the anaerobe Bacteroides fragilis to oxidative stress conditions, with a focus on the role of the transcriptional regulators BmoR and OxyR. At KU, I’m studying Caenorhabditis elegans developmental neurobiology, with a focus on the mechanisms controlling Q neuroblasts migration and differentiation in this organism. C. elegans neuroblasts migrate in a left-right asymmetric pattern from two Q neuroblasts that are initially located at similar positions on the left (QL) and right (QR) lateral side. By using a single-cell transcriptomics approach, we plan to identify early, cell-intrinsic differences in QL versus QR that govern their migration, and to elucidate the temporal dynamics of gene expression in Q cells as they differentiate.

Selected Publications —

  • Teixeira, F.L.; Costa, S.B.; Pauer, H.; Almeida, B.J.; Oliveira, A.C.S.C; Smith, J.; Domingues, R.M.C.P.; Rocha, E.R.; Lobo, L.A. Characterization of the oxidative stress response regulatory network in Bacteroides fragilis: An interaction between BmoR and OxyR regulons promotes abscess formation in a model of intra-abdominal infection. Anaerobe, 78:102668, 2022.
  • Pauer, H.; Teixeira, F.L.; Robinson, A.V.; Parente, T.E.; Melo, M.A.F.; Lobo, L.A.; Domingues, R.M.C.P.; Allen-Vercoe, E.; Ferreira, R.B.R.; Antunes, L.C.M. Bioactive small molecules produced by the human gut microbiota modulate Vibrio cholerae sessile and planktonic lifestyles. Gut Microbes, 13(1):1-19, 2021.
  • Teixeira, F. L.; Pauer, H.; Costa, S. B.; Smith, C. J.; Domingues, R. M. C. P.; Rocha, E.R.; Lobo, L.A. Deletion of BmoR affects the expression of genes related to thiol/disulfide balance in Bacteroides fragilis. Scientific Reports, 8:4405, 2018.
  • Teixeira, F.L.; Domingues, R.M.C.P.; Lobo, LA. Regulation of oxidative stress–related genes implicated in the establishment of opportunistic infections by Bacteroides fragilis In: Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria.1st ed.: John Wiley & Sons, Inc., 2016.
  • Teixeira, F.L.; Silva, D.N.S.; Pauer, H.; Ferreira, L.Q.; Ferreira, E.O.; Domingues, R.M.C.P.; Lobo, L.A. The role of BmoR, a MarR Family Regulator, in the survival of Bacteroides fragilis during oxidative stress. International Journal of Medical Microbiology, 303:443-448, 2013.