Caetano Antunes

Caetano Antunes
  • Assistant Professor


Caetano holds a B.Sc. (2000) and M.Sc. (2002) in Microbiology from Universidade Federal do Rio de Janeiro (Rio de Janeiro, Brazil). He completed his Ph.D. at the University of Iowa (2003-2007) and then moved to Canada for his post-doctoral studies (2008-2012) at the University of British Columbia. In 2012, Caetano was a Researcher in Public Health at Fundação Oswaldo Cruz, in Rio de Janeiro, Brazil. Caetano and his group transitioned to KU in January 2023.


Ph.D., University of Iowa, 2007, Iowa City, Iowa
M.S. in Microbiology, Universidade Federal do Rio de Janeiro, 2002


Caetano´s research group is interested in the role of small molecules in host-microbe interactions. In particular, they study the impact of microbiome-derived small molecules on bacterial pathogen gene expression and behavior. Caetano and his group have shown that the human gut is teeming with small molecules, and that the gut metabolome controls expression of various virulence attributes in enteric pathogens.

Selected Publications

  1. Pauer, H.; Teixeira, F.L.; Robinson, A.V.; Parente, T.; Melo, M.; Lobo, L.A.; Domingues, R.M.; Allen-Vercoe, E.; Ferreira, R.B.; Antunes, L.C.M. 2021. Bioactive small molecules produced by the human gut microbiome modulate Vibrio cholerae sessile and planktonic lifestyles. Gut Microbes. 13(1):1-19.

  2. Pina, L.C.; da Silva, F.S.; Galvão, T.C.; Pauer, H.; Ferreira, R.B. and Antunes, L.C.M. 2021. The role of two-component regulatory systems in environmental sensing and virulence in Salmonella. Crit. Rev. Microbiol. 47(4):397-434.

  3. Glatthardt, T.; Campos, J.C.; Chamon, R.C.; de Sá Coimbra, T.F.; Rocha, G.A.; de Melo, M.A.; Parente, T.E.; Lobo, L.A.; Antunes, L.C.M.; dos Santos, K.R. and Ferreira, R.B. 2020. Small molecules produced by commensal Staphylococcus epidermidis disrupt formation of biofilms by Staphylococcus aureus. Appl. Environ. Microbiol. 86(5):e02539-19.

  4. Pires, E.S.; Hardoim, C.C.; Miranda, K.R.; Secco, D.A.; Lobo, L.A.; de Carvalho, D.P.; Han, J.; Borchers, C.H.; Ferreira, R.B.; Salles, J.F.; Domingues, R.M. and Antunes, L.C.M. 2019. The gut microbiome and metabolome of two riparian communities in the Amazon. Front. Microbiol. 10:2003.

  5. Peixoto, R.J.; Alves, E.; Wang, M.; Ferreira, R.B.; Granato, A.; Han, J.; Gill, H.; Jacobson, K.; Lobo, L.A.; Domingues, R.M.; Borchers, C.H.; Davies, J.E.; Finlay, B.B. and Antunes, L.C.M. 2017. Repression of Salmonella host cell invasion by aromatic small molecules from the human fecal metabolome. Appl. Environ. Microbiol. 83(19):e01148-17.

  6. Antunes, L.C.M.; McDonald, J.A.; Schroeter, K.; Carlucci, C.; Ferreira, R.B.; Wang, M.; Yurist-Doutsch, S.; Hira, G.; Jacobson, K.; Davies, J.; Allen-Vercoe, E. and Finlay, B.B. 2014. Antivirulence activity of the human gut metabolome. MBio. 5(4): e01183-14.

  7. Antunes, L.C.M.; Arena, E.T.; Menendez, A.; Han, J.; Ferreira, R.B.; Buckner, M.M.; Lolić, P.; Madilao, L.L.; Bohlmann, J.; Borchers, C.H. and Finlay, B.B. 2011. Impact of Salmonella infection on host hormone metabolism revealed by metabolomics. Infect. Immun. 79(4):1759-1769.

  8. Antunes, L.C.M.; Han, J.; Ferreira, R.B.; Lolić, P.; Borchers, C.H. and Finlay, B.B. 2011. Effect of antibiotic treatment on the intestinal metabolome. Antimicrob. Agents Chemother. 55(4):1494-1503.