Three-year grant will fund study on coronavirus evolution and that effect on viral replication
Tony Fehr and Rob Unckless, Associate Professors of Molecular Biosciences, received $1M from the National Science Foundation for a three-year project titled “Determining how the evolution of the coronavirus macrodomain contributes to its biochemical and virological functions”
This award aims to define how the coronavirus macrodomain has evolved to best function in the context of a virus infection by evaluating the impact of a wide variety of mutations have on the biochemistry of Mac1 and their impact on viral replication and pathogenesis.