Fusao Takusagawa

Fusao Takusagawa
  • Emeritus Professor

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Biography —

  • Director of X-ray Crystallography Laboratory, and Associate Scientist, University of Kansas, Lawrence, KS, 9/1984 - 7/1995.
  •  Director of X-ray Crystallography Laboratory, Senior Scientist, and Research Professor, University of Kansas, Lawrence, KS, 9/1995 - 7/1996.
  • Associate Professor, Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 8/1996 - 8/2001
  • Professor, Department of Molecular Biosciences, University of Kansas, Lawrence, KS, 8/2001 - 2017

Fusao Takusagawa retired from KU in 2017.

Education —

B.S. in Chemical Engineering, Yamanashi University, Yamanashi, Japan
Ph.D. in Physical Chemistry, Osaka City University, Osaka, Japan
Ph.D. in Postdoctoral Research: E.R.D.A, Ames Laboratory, Iowa State University

Research —

  • Structure and function of proteins and nucleic Acids.
  • Design and synthesis of anti-viral and anti-cancer drugs.
  • Development of computer software for crystallography.

Selected Publications —

  • Takusagawa F & *Koetzle TF (1979). A Neutron Diffraction Study of the Crystal Structure of Ferrocence. Acta Cryst. B35, 1074
  • Devore DD, Lichtenhan JD, *Maata EA & Takusagawa F (1987). Complexes of (Arylimido)vanadium(V): Synthetic,

    Structural, Spectroscopic and Theoretical Studies of V(Ntol) Cl3 and Derivatives. J. Am. Chem. Soc. 109, 7408.
  • Kamitori S & *Takusagawa F (1992). Crystal Structure of 2:1 Complex Between d(GAAGCTTC) and Anticancer Drug Actinomycin. J. Mol. Biol. 225, 445.
  • Takusagawa F, Kamitori S, Misaki S & Markham GD (1996). Crystal Structure of S-Adenosylmethionine Synthetase. J. Biol. Chem. 271, 136-147.
  • Takusagawa F, Kamitori S & Markham GD (1996). Structure and Function of S- Adenosylmethionine Synthetase: Crystal Structure of S-Adenosylmethionine Synthetase with ADP, Br-ADP, PPi at 2.8Å Resolution. Biochemistry 35, 2586- 2596.
  • Komoto J, Yamada T, Watanabe K, & *Takusagawa F (2004). Crystal structure of Human prostaglandin F synthase (AKR1C3). Biochemistry 43, 2188-2198.

Grants & Other Funded Activity —

  • NIH: Study of interaction between DNA and antibiotics
  • NIH: Structural studies of important enzymes
  • Wesley Foundation: Study of DNA-drug interaction using X-ray crystallography
  • NIH: Structural studies of important enzymes
  • Kansas Health Foundation: Study of RNA-DNA hybrid binding agents
  • J.R. & I. Jay Res. Fund: Roles of amino acids in actinomycin D
  • NIH: Structural studies of important enzymes
  • NIH: Structural studies of important enzymes
  • NIH: Structural studies of important enzymes
  • AmHeart: Studies of hyperhomocysteinemia
  • Allegan Inc: Research of Endocrabinoids Synthase
  • Arthritis Foundation: A study of prostaglandin E synthase induced by inflammatory responses
  • KCALI: Control of Gap Junctions as a Neuro-protective Therapy

Training Grants

  • NIH: Medicinal Chemistry & Pharmacology
  • NIH: Training Grant in Dynamic Aspects of Chemical Biology
  • NIH: Training Grant in Dynamic Aspects of Chemical Biology
  • NIH: Training Grant in Dynamic Aspects of Chemical Biology
  • NIH: Pharmaceutical Aspects of Biotechnology Training Grant