January 2015 News

Dr. Liang Xu Liang Xu (associate professor) is the recipient of a private donation through the University of Kansas Endowment from relatives of a patient recently diagnosed with late stage pancreatic cancer.  The goal of this project is to find new therapies for pancreatic cancer by targeting pancreatic cancer stem cells.




Lauren ArneyLauren Arney (undergraduate, Lamb lab) is the recipient of a Spring 2015 KU Undergraduate Research Award. The $1000 stipend provide support to pursue an independent research project.  Lauren will study allosterism in liver pyruvate kinase using x-ray crystallography.



Emily BinshtokEmily Binshtok (undergraduate, Xu Lab) is the recipient of a Spring 2015 KU Undergraduate Research Award. The $1000 stipend provides support to pursue an independent research project.  The title of her project is “The Therapeutic Value of Anti-Metastatic MicroRNAs in Breast Cancer.”



Graham Wehmeyer Graham Wehmeyer (undergraduate, Egan Lab) is the recipient of a Del and Carol Shankel Biomedical Scholarship.




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January 2015 Presentations

Erik Lundquist (professor) gave a seminar presentation at the University of Minnesota Department of Genetics, Cell Biology, and Development entitled “Mechanisms of Netrin-mediated axon repulsion”, December 4.

Sriram Varahan (Hancock lab) successfully defended his doctoral dissertation entitled “Role of Enterococcal Membrane Proteins in Cell-Cell Communication and Stress Adaptation” on December 10.

Mauricio Galdos (Blumenstiel lab) successfully defended his masters thesis entitled “Identifying Factors That Control Germline Transposable Element Activity in Drosophila” on December 17.

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January 2015 Publications

Deng L, Shang L, Bai S, Chen J, He X, Trevino RM, Chen S, Li X, Meng X, Yu B, Wang X, Liu Y, McDermott SP, Ariazi AE, Ginestier C, Ibarra I, Ke J, Luther TK, Clouthier SG, Xu L, Shan G, Song E, Yao H, Hannon GJ, Weiss SJ, Wicha MS, Liu S. microRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development. Cancer Research 74, 6648-6660.

Edgerton H, Paolillo V, Oakley BR.  Spatial regulation of the spindle assembly checkpoint and anaphase promoting complex in Aspergillus nidulans.  Molecular Microbiology.  [Epub ahead of print]

Lamb AL, Kappock TJ, Silvaggi NR.  You are lost without a map: navigating the sea of protein structuresBiochim Biophys Acta [Epub ahead of print]

Li K, Liu H, Gao W, Chen M, Zeng Y, Liu J, Xu L, Wu D.  Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy.  Biomaterials 2015; 39(1):131-144.

Lu J, Zhao W, Liu H, Marquez R, Huang Y, Zhang Y, Li J, Xie W, Venkataramanan R, Xu L, Li S.  An Improved D-α-Tocopherol-Based Nanocarrier for Targeted Delivery of Doxorubicin with Reversal of Multidrug Resistance.  Journal of Controlled Release [Epub ahead of print]

Smith MC, Box AC, Haug JS, Lane WS, Davido DJA Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 GenomesCells 3, 1131-1158.

Tewary SK, Liang L, Lin Z, Lynn A, Cotmore SF, Tattersall P, Zhao H, Tang LStructures of minute virus of mice replication initiator protein N-terminal domain: Insights into DNA nicking and origin bindingVirology.  [Epub ahead of print]

Wang B, Chen L, Ni Z, Dai X, Qin L, Wu Y, Li X, Xu L, Lian J, He F.  Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells.  Experimental Cell Research, 2014. 328(2):379-387.

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Molecular Biosciences

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Yamini Mutreja (graduate student, Gamblin lab) presented a poster entitled "Mutations in Tau have Differential Effects on the Aggregation and Microtubule Stabilization Properties of its Isoforms" at the 2014 American Society for Cell Biology Annual Meeting on December 9th in Philadelphia, PA. http://ascb.org/
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