November 2020 News

Ronak Tilvawala (assistant professor) in collaboration with Tony Fehr (assistant professor) received a CBID CoBRE grant entitled "Host Substrate Profiling of SARS-CoV-2 Virus Protease".

 

 

Erik Lundquist (professor) received an NIH R01 research award from the National Institute of Neurological Disorders and Stroke entitled “Regulation of Directed Neuroblast Migration by the Extracellular Matrix and MAB-5/Hox”.

 

 

Dan Dixon (professor) was awarded a voucher from the IDeA National Resource for Quantitative Proteomics to examine inflammation-associated exosomes.

 

 

 

Liang Xu (professor) received a Pilot Project Award from KU Cancer Center, entitled “Drug the Undruggable Musashi Oncoprotein by Fragment-based Drug Discovery”. Yinglong Miao (assistant professor) is a co-investigator on this project.

 

 

Three Molecular Biosciences faculty were selected for The University of Kansas Cancer Center 2020 Director’s Awards in recognition of “individuals who have significantly contributed to the Cancer Center’s mission of reducing the burden of cancer in our region.” Dan Dixon and Liang Xu received the William Jewell Team Science Award and Kristi Neufeld received the Director’s Mentoring Award. Dixon and Neufeld, who serve as Cancer Center program co-leaders each planned and moderated several sessions during KUCC research week, October 26-30.

Tom Hill (postdoc, Unckless lab) accepted a position as a Bioinformatics Analyst at the National Cancer Institute at Frederick in Frederick, Maryland. Congratulations Tom!

 

 

 

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Presentations

Yinglong Miao (assistant professor) gave an invited talk entitled "Accelerated Molecular Simulations and Computer-Aided Drug Design" to the Chemistry Colloquium, Illinois Institute of Technology, Virtual, October 13, 2020.

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Publications

Wang, J. and Miao, Y*. (2020) Peptide Gaussian accelerated molecular dynamics (Pep-GaMD): Enhanced sampling and free energy and kinetics calculations of peptide binding. Journal of Chemical Physics.

Conrad M, Soldner CA, Miao Y, & Sticht H. (2020) Agonist Binding and G Protein Coupling in Histamine H2 Receptor: A Molecular Dynamics Study. International Journal of Molecular Sciences.

Tom Hill and Rob Unckless. (2020) Adaptation, ancestral variation and gene flow in a ’Sky island’ Drosophila species. Molecular Ecology.

Legrand N, Dixon DA, Sobolewski C. (2020) Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications. World J Gastroenterol.

C.D. Heer, L.S. Voth, D.J. Sanderson, Y.M.O. Alhammad, M.S. Schmidt, S.A.J. Trammell, S. Perlman, M.S. Cohen, A.R. Fehr, and C. Brenner. (2020). Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity. J Biol Chem.

S. Ghosh, T.A. Dellibovi-Ragheb, E. Pak, Q. Qui, M. Fisher, P.M. Takvorian, C. Bleck, V. Hsu, A.R. Fehr, S. Perlman, S.R. Achar, M.R. Straus, G.R. Whittaker, C.A.M. de Haan, G. Altan-Bonnet, and N. Altan-Bonnet. (2020) B-Coronaviruses use lysosomal organelles for cellular egress. Cell In press.

Y.M.O. Alhammad, M.M. Kashipathy, A. Roy, J.P. Gagne, L. Nonfoux, P. McDonald, P. Gao, K.P. Battaile, D.K. Johnson, G.G. Poirier, S. Lovell, and A.R. Fehr. (2020) The SARS-CoV-2 conserved macrodomain is a highly efficient ADP-ribosylhydrolase. J Virol. In press.

Jennifer R Klaus, Pauline M L Coulon, Pratik Koirala, Mohammad R Seyedsayamdost, Eric Déziel, Josephine R Chandler. (2020)  Secondary metabolites from the Burkholderia pseudomallei complex: structure, ecology, and evolution. J. Industrial Mcrb. & Biotech.

Jennifer R Klaus, Charlotte Majerczyk, Stephanie Moon, Natalie A Eppler, Sierra Smith, Emily Tuma, Marie-Christine Groleau, Kyle L Asfahl, Nicole E Smalley, Hillary S Hayden, Marianne Piochon, Patrick Ball, Ajai A Dandekar, Charles Gauthier, Eric Déziel, Josephine R Chandler. (2020) Burkholderia thailandensis methylated hydroxy-alkylquinolines: biosynthesis and antimicrobial activity in co-cultures. AEM.

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Molecular Biosciences

We are an interdisciplinary group of faculty who perform cutting edge research in a wide range of areas including biochemistry, biophysics, structural biology, bioinformatics, cancer biology, genetics, genomics, immunology, microbiology, virology, neurobiology, molecular, cellular and developmental biology.  We work closely with postdoctoral fellows, graduate students, and undergraduates to investigate fundamental biological problems on all levels from molecules to cells to organisms.  The Department of Molecular Biosciences, located on the Lawrence campus of the University of Kansas system, is an excellent environment for research and education.

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