July 2019 News

Ilya Vakser (professor) received a grant from the National Science Foundation entitled "Structural modeling of interactome to assess phenotypic effects of genetic variation.” The goal of the project is the development of high-throughput, structure-based methodologies and public resources for modeling of protein interaction networks and assessing the function of single amino acid variation. The project is a collaboration with Professor Michael Sternberg at the Imperial College London.

 

Tori Paolillo (postdoc, Lundquist lab) received a K-INBRE post-doctoral award to study the transcriptomics of neuroblast migration in C. elegans.

 

 

 

Jeff McFarlane (graduate student, Lamb lab) successfully defended his dissertation entitled “The Biosynthesis of Opine Metallophores” on June 21.  In August, Jeff will become an Assistant Professor at Fort Lewis College in Durango, Colorado.

 

 

Rhea Abisado (graduate student, Chandler lab) gave an invited talk at the American Society of Microbiology Microbe meeting in San Francisco on June 24 entitled “Quorum sensing control of tobramycin resistance in Pseudomonas aeruginosa.

 

 

 

 

The 22nd International C. elegans Meeting was held at UCLA in Los Angeles, June 26-29.  The main sponsor of the meeting, the Genetics Society of America, was represented by former KUMB graduate students, Sonia Hall and Erin Suderman, both from Rob Ward’s lab.  Three current KUMB students had poster presentations at the meeting:  Zhe Yang (graduate student, Buechner lab) “The RNA-Binding Proteins EXC-7 and MSI-1 Upregulate Serotonin Signaling in the Male Tail”, Snehal Mahadik (graduate student, Lundquist lab) “SRC-1 Is the Negative Regulator of UNC-5 in the Polarity/Protrusion Model of Directed Growth Cone Outgrowth”, and Matthew Ochs (graduate student, Lundquist lab) “Using Fluorescence-Activated Cell Sorting and RNA-Seq to Identify mRNA Targets of ETR-1/CELF that Regulate Q Neuroblast Migration”

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July 2019 Presentations

Stuart Macdonald (professor) gave an invited talk entitled "Genomewide expression analysis of the adult female gut in the Drosophila Synthetic Population Resource" at the Complex Traits Consortium / Rat Genomics 17th Annual Meeting, San Diego CA, June 8-11.

Dan Dixon (associate professor) gave an invited talk entitled "Reaching outside the tumor cell: Control of exosome secretion by HuR" at the 8th mRNA Stability Conference: Mechanisms, Regulation and their Implication in Infectious and Age Related Diseases, June 25-28, Montreal, Canada.

Yinglong Miao (assistant professor) gave an invited talk entitled “Gaussian Accelerated Molecular Dynamics: Free Energy Calculations of Biomolecular Interactions.” Santa Fe Workshop “Free energy calculations: Entering the fourth decade of adventure in chemistry and biophysics (2019)Santa Fe, NM. June 16 – 21, 2019.

 

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July 2019 Publications

Gujar MR, Stricker AM, Lundquist EA (2019) RHO-1 and the Rho GEF RHGF-1 interact with UNC-6/Netrin signaling to regulate growth cone protrusion and microtubule organization in Caenorhabditis elegans. PLoS Genet 15(6): e1007960.

McFarlane JS, Ronnebaum TA, Meneely KM, Chilton A, Fenton AW, Lamb ALChanges in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-π bondActa Crystallogr F Struct Biol Commun. 75, 461-469.

Tom Hill, Boryana S. Koseva, Robert L. Unckless. The Genome of Drosophila innubila Reveals Lineage-Specific Patterns of Selection in Immune Genes” in Molecular Biology and Evolution. Mol.Biol.Evol. 36(7):1405-1417.

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Molecular Biosciences

We are an interdisciplinary group of faculty who perform cutting edge research in a wide range of areas including biochemistry, biophysics, structural biology, bioinformatics, cancer biology, genetics, genomics, immunology, microbiology, virology, neurobiology, molecular, cellular and developmental biology.  We work closely with postdoctoral fellows, graduate students, and undergraduates to investigate fundamental biological problems on all levels from molecules to cells to organisms.  The Department of Molecular Biosciences, located on the Lawrence campus of the University of Kansas system, is an excellent environment for research and education.

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