Ph.D., Massachusetts Institute of Technology, 1962
B.S., 1958, University of California at Berkeley
Ph.D., 1962, Massachusetts Institute of Technology
Solon E. Summerfeld Distinguished Professor
Professor Schowen has closed his research groups, but continues to work in collaboration with colleagues at Kansas and elsewhere. Active programs at Kansas include these projects: (1) Studies of the mechanism, involvement of protein dynamics, and antiparasitic drug design for S-adenosylhomocysteine hydrolases (led by R.T. Borchardt with collaboration by J. Fang, Lynne Howell [Toronto], Carey Johnson, Krzysztof Kuczera, C.R. Middaugh, and Morris Robins [Brigham Young University]); (2) Design and characterization of “green catalysts” with R.S. Givens and others in the NSF Center for Environmentally Beneficial Catalysis, led by Daryle Busch and Bala Subramaniam; (3) Protium-deuterium exchange in the amorphous solid state as a measure of protein mobility, led by Elizabeth M. Topp.
Y. Li, E.M. Topp, R.L. Schowen, Characterizing protein structure in amorphous solids using hydrogen/deuterium exchange with mass spectrometry, Anal Biochem. 2007, 366. 18-28.
R.L. Schowen, The Use of solvent isotope effects in the pursuit of enzyme mechanisms, Journal of Labelled Compounds and Radiopharmaceuticals 2007, 50, 1052-1062.
Sumin Cai, Qing-Shan Li, Ronald T. Borchardt, Krzysztof Kuczera, Richard L. Schowen, The antiviral drug ribavirin is a selective inhibitor of S-adenosyl-L-homocysteine hydrolase from Trypanosoma cruzi, Bioorganic and Medicinal Chemistry2007, 15, 7281-7287.
C. Hu, J. Fang, R.T. Borchardt, R.L. Schowen, K. Kuczera, Molecular dynamics simulations of domain motions of substrate-free S-adenosyl-L-homocysteine hydrolase in solutions, Proteins 2008, 71, 131-143.
Richard S. Givens, Dominik Heger, Bruno Hellrung, Yavor Kamdzhilov, Marek Mac, Peter G. Conrad, II, Elizabeth Cope, Jong I. Lee, Julio F. Mata-Segreda, Richard L. Schowen and Jakob Wirz, The Photo-Favorskii Reaction of p-Hydroxyphenacyl Compounds is Initiated by Water-Assisted, Adiabatic Extrusion of a Triplet Biradical, J. Am. Chem. Soc.2008, 130, 3307-3309.
Qing-Shan Li; Sumin Cai; Jianwen Fang; Ronald T. Borchardt; Krzysztof Kuczera; C. Russell Middaugh; Richard L. Schowen, Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix-18 stability, Biochemistry 2008, 47, 4983-4991.
K. Anandarajah, K.B. Schowen, and R.L. Schowen, Hydrogen tunneling in glucose oxidation by the archaeonThermoplasma acidophilum, Zeitschrift für physikalische Chemie 2008, 222, 1333-1347.
R.L. Schowen, Strengths and weaknesses of model reactions for the assessment of tunneling in enzymic reactions, Ch. 12 in Quantum Tunneling in Enzyme-Catalysed Reactions (R.K. Allemann and N.S. Scrutton, eds.), Royal Society of Chemistry, London, 2009.
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