Yousef Alhammad, Ph.D.
- Tony Fehr Lab
Hometown: Saudia Arabia
Current Research: My main project is to study and understand coronaviruses macrodomains. The coronaviruses encode this structurally conserved domain within the nsP3 of all lineages, including the MHV, SARS-CoV, MERS-CoV and SARS-CoV-2. The interest of this protein due to the fact that it has an enzymatic activity to remove ADP-ribose from target proteins and therefore any drug targeting this protein may have broad antiviral activity against various coronaviruses. To study the function of this protein I used different approaches in vitro and in vivo in actual viruses using BSL-2 and the BSL-3 facility that recently has been constructed at the KU.
Selected Publications —
- Alhammad, Y. M., Kashipathy, M. M., Roy, A., Gagné, J. P., McDonald, P., Gao, P., ... & Poirier, G. G. (2020). The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase. Journal of virology.
- Alhammad, Y. M., & Fehr, A. R. (2020). The viral macrodomain counters host antiviral ADP-ribosylation. Viruses, 12(4), 384.