Josephine (Josie) Chandler

Assistant Professor
Primary office:
(785) 864-5329
7041 Haworth Hall

Mechanisms and Role of Social Behavior in Bacteria

Dr. Chandler's research is focused on understanding how bacteria communicate and cooperate with each other to carry out complex group behaviors. She primarily studies a cell-cell communication system in bacteria called quorum sensing. Most quorum sensing systems become activated when the bacterial population reaches a critical cell density. Quorum sensing commonly controls production of extracellular factors, such as toxins, exoenzymes, and components involved in self-structured biofilm-like communities. Production of extracellular factors often involves cooperation because the factors can be shared among all of the members of a population. Much is known about the molecular biology of quorum sensing, but our understanding of its role in promoting group or cooperative activities remains obscure. Using Burkholderia thailandensis as a model, Dr. Chandler developed laboratory systems to understand how quorum sensing and cooperation are important for 1) competition between bacteria using antibiotics and 2) formation of self-structured communities. This work will promote our ability to create, maintain and manipulate cooperating bacterial communities that carry out important biological functions. In addition, bacteria serve as an excellent model for understanding the evolution of sociality.

Representative Publications

  • Chandler JR, T Truong, PM Silva, M Radey, MA Jacobs, EH Sims, MR Seyedsayamdost, G Carr, J Clardy and EP Greenberg. 2012. Bactobolin resistance is conferred by mutations in the L2 ribosomal protein. mBio 3:e00499.
  • Goo E, CD Majerczyk, JH An, JR Chandler, Y-S Seo, H Ham, H Kim, B Lee, MS Jang, EP Greenberg and I Hwang. 2012. Quorum sensing, cooperativity and anticipation of stationary phase stress. Proc Natl Acad Sci USA 109:19775.
  • Chandler JR, S Heilmann, JE Mittler and EP Greenberg. 2012. Acyl-homoserine lactone- dependent eavesdropping promotes competition in a laboratory co-culture model. ISME J 6:2219.
  • Carr G, MR Seyedsayamdost, JR Chandler, EP Greenberg and J Clardy. 2011. Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264. Org Lett 13:3048.
  • Seyedsayamdost MR, JR Chandler, JA Blodgett, PS Lima, BA Duerkop, K Oinuma, EP Greenberg and J Clardy. 2010. Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Org Lett 12:716.
  • Chandler JR, BA Duerkop, A Hinz, TE West, JP Herman, MEA Churchill, SJ Skerrett and EP Greenberg. 2009. A mutational analysis of Burkholderia thailandensis quorum sensing and self- aggregation. J Bacteriol 191:5901.
  • Duerkop BA, J Varga, JR Chandler, SB Peterson, JP Herman, MEA Churchill, MR Parsek, WC Nierman and EP Greenberg. 2009. Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis. J Bacteriol 191:3909.
  • Mattmann ME, GD Geske, GA Worzalla, JR Chandler, KJ Sappington, EP Greenberg and HE Blackwell. 2008. Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. Bioorg Med Chem Lett 15:3072.

Home to 50+ departments, centers, and programs, the School of the Arts, and the School of Public Affairs and Administration
KU offers courses in 40 languages
Graduates of the College have won Emmys, discovered new species, and been named to Forbes' "most powerful women" lists
No. 1 ranking in city management and urban policy —U.S. News and World Report
One of 34 U.S. public institutions in the prestigious Association of American Universities
26 prestigious Rhodes Scholars — more than all other Kansas colleges combined
Nearly $290 million in financial aid annually
46 nationally ranked graduate programs.
—U.S. News & World Report
Top 50 nationwide for size of library collection.
—ALA
23rd nationwide for service to veterans —"Best for Vets," Military Times
Upcoming Events
There are no upcoming events at this time.
Christian Gomez (graduate student, Neufeld lab) presented a poster entitled “Goblet cells show increased APC levels in Mouse and Human intestinal tissue.” at the KU Cancer Center symposium on November 12.