David Ingham

Advisor:  Chris Gamblin
Research Interests:  The normal function of the tau protein is to associate and stabilize microtubules within the neuronal cytoskeleton. However, hyperphosphorylation of tau can dissociate from microtubules and lead to the formation of tau aggregates forming pathological structures such as neurofibrillary tangles and paired helical filaments. These structures have been identified in multiple neurodegenerative diseases such as Alzheimer's disease. I am interested in how small compounds can be used to not only inhibit the formation of these pathological structures, but also cause the disassembly of aggregates that have already formed.

Hometown:  Leeds, England